Quercetin vs Curcumin (Turmeric) 2022

Quercetin and curcumin are plant-derived natural compounds that are becoming widely studied because of their apparent therapeutic potential. Both are available as supplements for a wide assortment of conditions including cardiovascular disease, cancer, asthma, diabetes, and many more.

Understanding the differences between quercetin and curcumin will help you decide whether you want to take both or one of them!

What Is Quercetin and Curcumin?

Quercetin is a dietary flavonoid that is abundant in many fruits, vegetables.
Curcumin is a flavonoid polyphenol that is the active element in the spice, turmeric. 
quercetin vs curcumin

1. Quercetin and Curcumin Benefits

 

Both Quercetin and Curcumin have similar benefits. They are both antioxidant molecules with anti-proliferative, anti-inflammatory and immunosuppressive activities.

This study suggests that curcumin and to a lesser extent quercetin may offer therapeutic potential for the treatment of crystal-induced arthritis or rheumatoid arthritis.

Both curcumin and quercetin have protective effects, reduced the oxidative stress and stimulated the antioxidant defense. Curcumin had stronger antioxidant effects compared to quercetin, probably because of its higher bioavailability and absorption. (Source)
 
 
Can I Take Quercetin and Turmeric Together?

study shown that combining low concentrations of Quercetin and Curcumin yield similar or better anti-inflammatory effectiveness when compared to treatment with each agent alone. Moreover, they co-operate synergistically in the context of antimicrobial activity, with an increased effectiveness when compared to Quercetin or Curcumin alone at high concentrations.

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2. Dosage, Bioavailability, Food Sources, Side Effects

 
Quercetin
Curcumin
Dosage

Typical dosage ranges from 500-1000 mg. You can take it by mouth daily for up to 12 weeks.

Consult your doctor to determine the best dose.

One to three 500 mg capsules daily with or without food. 

However, Higher doses are associated with adverse side effects. Best to talk to your doctor to determine the best dose for you.

Bioavailability

Quercetin is not soluble in water, however, so it is a poorly absorbed nutrient. Bromelain, a protein-digesting enzyme extracted from pineapples, may boost quercetin absorption, as does vitamin C

Curcumin has multiple health benefits and are best achieved when curcumin is combined with agents such as piperine, which increase its bioavailability significantly. (Source)

Food Source

Apples, honey, raspberries, onions, red grapes, cherries, citrus fruits, and green leafy vegetables are high in quercetin. However, Onions have the greatest quercetin content of any vegetable or fruit.

Turmeric is the plant with the largest amount of curcumin. Turmeric is commonly sold in grocery shops as a ground spice as well as by the root.

Side effect

Most people who get quercetin naturally in normal dosage will experience no side effects.

There have been few reported side effects for quercetin supplements. But, in some studies, large doses of quercetin (over 1,000mg) were linked with headaches, digestive issues, and tingling sensations.

 
 
Turmeric is generally considered to be safe.
However,  It can cause nausea and diarrhea, especially when used in large dosages or over an extended period of time.
 
In excessive doses, it may potentially increase the risk of ulcers. 

c. Difference Between Curcumin and Quercetin

 
Quercetin is the most active flavonoid, with important anti-inflammatory and antioxidant effects, while curcumin has antioxidant effects that are similar to the standard antioxidants and exerts direct anti-inflammatory activity.

3. Precautions

a. Who should not take quercetin?

 

Pregnant women, breastfeeding women, and people with kidney disease should avoid quercetin. Moreover, you should avoid higher doses than 1 g per day, there have been reports of damage to the kidneys. (Source)

 

 
Quercetin may interact with a number of medications..
Antibiotics: May prevent the action of antibiotics
Blood thinners: Could increase the effects of blood-thinning medication
Chemotherapy: May interact with chemotherapeutic medication
Corticosteroids: Could cause these medications to stay in your body for longer
Cyclosporine: May interact with the absorption of this medicine
Digoxin: Could increase the risk of side-effects associated with this chemical agent
Fluoroquinolones: May decrease the effectiveness of these medicines
Medications altered/activated by the liver: Quercetin may change how your body metabolizes medicine that is activated in the liver 
 

b. Who should not take curcumin?

 

Best to ask a doctor first, if it is safe for you to take curcumin if you have ever had:

– Diabetes

– Gallbladder problems

– An iron deficiency

– Bleeding problems or a blood-clotting disorder

– A stomach disorder called gastroesophageal reflux disease (GERD);

– Endometriosis or uterine fibroids; or

– Cancer of the breast, uterus, ovary (or other hormone-sensitive conditions).

 

What should I avoid when taking turmeric?
Turmeric may make it more difficult for your body to absorb iron. Inform your doctor if you use an iron supplement.

Don’t use turmeric with other herbal/health products that may interfere with blood clotting. Angelica (dong quai), capsicum, clove, dandelion, danshen, evening primrose, garlic, ginger, ginkgo, horse chestnut, Panax ginseng, poplar, red clover, saw palmetto, and willow are all included.

Avoid combining turmeric with other herbal/health products that can lower blood sugar levels, such as alpha-lipoic acid, chromium, damiana, devil’s claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, Siberian ginseng, and others.

4. Best Quercetin Supplements

 

a. Quercetin – Amazing Formulas Quercetin

b. Quercetin with Bromelain – Now Foods Quercetin with Bromelain
Now Foods Quercetin supplements contain Bromelain, as some evidence suggests they boost absorption.

c. Quercetin with Vitamin C and Zinc – Whole Foods Quercetin Plus
Contains Bromelain, Zinc, Vitamin C and Ginger-Bioflavonoids. This supplement provides support for the immune, cardiovascular and respiratory system. Quercetin with vitamin C and zinc is proven not only to provide immune support but also to improve metabolism, circulatory supporty, and cognitive clarity.

d. Quercetin with Bromelain and Vitamin C – ForestLeaf Quercetin with Bromelain + Vitamin C
Quercetin with Bromelain, Stinging Nettle and Vitamiin C may help with sinus relief, allergies, cardiovascular and respiratory health. 

e. Quercetin with Turmeric – Organic Cadane Quercetin Capsule
This organic Quercetin extract product is the supermix capsules, includes Quercetin, Turmeric Curcumin, Berberine, Stinging Nettle, Black Seed powder, Black Pepper and is suitable for vegans.

 

5. Best Curcumin Supplements

 

a. Curcumin with BioPerine Black Pepper Extract – NatureWise Organic Curcumin Turmeric 2250mg, 95 Curcuminoids
Curcumin by itself is poorly absorbed by the body. This turmeric with black pepper capsules are enhanced with ginger and Bioperine, a patented black pepper extract proven to dramatically increase bioavailability.

b. Curcumin Elite Turmeric Extract – Life Extension Curcumin Elite Turmeric Extract
This supplement combined curcumin from turmeric, a spice steeped in Ayurvedic tradition, with fibers from fenugreek seeds. This formula offers more bioavailable free curcuminoids and better absorption of total curcuminoids than standard curcumin.

6. Best Quercetin and Curcumin Supplements

 
a. Quercetin with Curcumin – Organic Cadane Quercetin Capsule
This organic Quercetin extract product is the supermix capsules, includes Quercetin, Turmeric Curcumin, Berberine, Stinging Nettle, Black Seed powder, Black Pepper and is suitable for vegans.

b. Best Quercetin, Bromelain, Curcumin and Piperine Supplement – Vimerson Health Turmeric, Quercetin, Bromelain
This supplement contains 500mg of Quercetin which acts as a strong antioxidant, balancing inflammation in your body and providing immune support. It also contains Bromelain which also balances inflammation, helping you to maintain a healthy immune system.
 
Finally, this supplement contains 700 mg of Organic Turmeric powder and 10mg of BioPerine black pepper extract for joint health. 
 
c. Best Quercetin, Bromelain and Curcumin Supplement – Vital Nutrients BCQ
This formula contains Boswellia and curcumin extracts, quercetin, a potent flavonoid and bromelain, a proteolytic enzyme derived from pineapple. These enzymes support healthy digestive and gastrointestinal function. This formula also supports healthy connective tissue and acts as an anti-inflammatory supplement, which may aid with minor pain relief.