Quercetin vs Astaxanthin 2022

Quercetin vs Astaxanthin

Quercetin and Astaxanthin are great antioxidants and offer lots of health benefits. Both are available as supplements for a wide assortment of conditions including cardiovascular disease, cancer, asthma, diabetes, and many more.

Understanding the differences between quercetin and astaxanthin will help you decide which one is the best for you.

Quercetin vs Astaxanthin

1. What is Quercetin?

Onions have the greatest quercetin content of any vegetable or fruit

Quercetin is a flavonoid found in fruits and vegetables, including red wine, onions, green tea, apples, and berries. Quercetin is most typically used to treat heart and blood vessel disorders, as well as to prevent cancer. It is also claimed to treat arthritis, bladder infections, and diabetes, but there is little scientific evidence to back up the majority of these claims.

Quercetin is also available as supplement and since Quercetin is not soluble in water, however, so it is a poorly absorbed nutrient. Bromelain, a protein-digesting enzyme extracted from pineapples, may boost quercetin absorption, as does vitamin C. Therefore, quercetin is often offered in combination with one or both additives.

2. What is Astaxanthin?

Astaxanthin food sources
Salmon contain astaxanthin, a carotenoid that gives salmon their reddish-orange hue

Astaxanthin is a red pigment that belongs to a group of chemicals called carotenoids. It is found in abundance in nature and is the primary pigment in crustaceans and salmonid fish.

Astaxanthin is an antioxidant which may protect cells from harm. Astaxanthin may also help the immune system work better. Because they offer many health benefits, astaxanthin is increasingly being used as a nutritional supplement in meals, feeds, nutraceuticals, and medications.

Astaxanthin is also available as a food supplement, but, like other carotenoids, is a very lipophilic compound and has low oral bioavailability. However, bioavailability can be enhanced in the presence of fat. (Source)

3. Quercetin and Astaxanthin are great for heart health

Both Quercetin and Astaxanthin are great antioxidants which may give benefits for heart heath and disease.

Quercetin and its derivatives improve heart features, implying that quercetin has the potential to be utilized therapeutically in the treatment of cardiac diseases.

Quercetin exhibits significant heart related benefits as inhibition of LDL oxidation, endothelium-independent vasodilator effects, reduction of adhesion molecules and other inflammatory markers, the protective effect on nitric oxide and endothelial function under conditions of oxidative stress, prevention of neuronal oxidative and inflammatory damage and platelet antiaggregant effects. (Source)

Aside from quercetin, there is also a research showed that astaxanthin may reduce oxidative stress and inflammation, both of which are associated with cardiovascular disease.

A study suggest that astaxanthin is a potent antioxidant and is associated with membrane preservation, it may protect against oxidative stress and inflammation and provide cardiovascular benefits.

4. Quercetin and Astaxanthin as chemoprevention agents

Tissue oxidative damage can result in malignant development. Therefore, increasing the quantities of antioxidants in body tissues may lead to cancer prevention. Many studies suggest that astaxanthin and quercetin which have high antioxidant can become anticancer agents.

A study shown that astaxanthin may offer protection from prostate cancer by inhibiting the enzyme responsible for prostate growth. Astaxanthin has also been shown to induce xenobiotic-metabolizing enzymes in rat liver, a process that may help prevent carcinogenesis.

It is also shown that carotenoids’ role in cell communications at cell-gap junctions (by up-regulating gene expression) may play a role in slowing the growth of cancer cells (Source)

Quercetin also has been shown to inhibit the proliferation of a wide range of cancers such as prostate, cervical, lung, breast, and colon. Recent studies have revealed that quercetin inhibits cell proliferation by causing apoptosis and/or cell cycle arrest. (Source)

5. Astaxanthin but not Quercetin improve heat-induced skeletal muscle oxidative injury

Heat stress causes mitochondrial dysfunction and increases mitochondrial production of reactive oxygen species (ROS), both of which contribute to heat-induced skeletal muscle injury.

A study tested whether either astaxanthin or quercetin could ameliorate heat-induced skeletal muscle oxidative injury. The result is that astaxanthin but not quercetin preserves mitochondrial integrity and function and ameliorates heat-induced skeletal muscle injury. Therefore astaxanthin may potentially be an effective preventive strategy. (Source)

6. Astaxanthin may more powerful than Quercetin

Astaxanthin is a superior antioxidant and is referred to as “super vitamin E” because its antioxidant activity outperforms that of other carotenoids, including -carotene, canthaxanthin, lutein, and zeaxanthin, as well as vitamins C and E, particularly in quenching singlet oxygens and scavenging free radicals. (Source)

Moreover, Astaxanthin was also found more powerful than resveratrol and quercetin.

However, Quercetin is considered to be a strong antioxidant due to its ability to scavenge free radicals and bind transition metal ions. (Source)

Quercetin and Astaxanthin Supplements

7. Best Quercetin Supplements


a. Quercetin – Amazing Formulas Quercetin


b.  Quercetin with Bromelain – Now Foods Quercetin with Bromelain

Now Foods Quercetin supplements contain Bromelain, as some evidence suggests they boost absorption.

c. Quercetin with Vitamin C and Zinc – Whole Foods Quercetin Plus

Contains Bromelain, Zinc, Vitamin C and Ginger-Bioflavonoids. This supplement provides support for the immune, cardiovascular and respiratory system. Quercetin with vitamin C and zinc is proven not only to provide immune support but also to improve metabolism, circulatory supporty, and cognitive clarity.
Quercetin with Bromelain, Stinging Nettle and Vitamiin C may help with sinus relief, allergies, cardiovascular and respiratory health. 
This organic Quercetin extract product is the supermix capsules, includes Quercetin, Turmeric Curcumin, Berberine, Stinging Nettle, Black Seed powder, Black Pepper and is suitable for vegans.

8. Best Astaxanthin Supplements


a. Astaxanthin 4mg – NOW Supplements, Astaxanthin 4 mg

Derived from Non-GMO Haematococcus Pluvialis Microalgae and has naturally occurring Lutein, Canthaxanthin and Beta-Caroten. Other Ingredients: Safflower Oil, Softgel Capsule (gelatin, water, glycerin) and Vitamin E (as natural d-alpha tocopherol). Vitamin E from soy


b. Astaxanthin 10mg – We Like Vitamins Astaxanthin 10mg

Ingredients: Natural Astaxanthin, Gelatin, Glycerol, Purified Water, Soybean Oil, non-GMO Natural Tocopherols.


c. Astaxanthin 12 mg – NUTREX HAWAII Astaxanthin 12 mg

Ingredients: Natural Hawaiian Astaxanthin (from Haematococcus pluvialis microalgae), Other Ingredients: high oleic safflower oil, gelatin, glycerin, purified water, natural tocopherols, Also contains naturally occuring carotenoids including lutein in a synergistic blend.

9. Recommended Dose

a. Quercetin Recommended Dose
How Much Quercetin Should You Take Per Day?
Researchers typically use a dose of 500 mg of quercetin per day in supplement form. Most quercetin supplements contain between 500 and 1200 mg of quercetin, although this can vary. Check out the nutritional label for your quercetin supplement to be sure.

Quercetin Dosage for Hay Fever
Experts recommend taking 400mg of quercetin twice a day between meals for hay fever. Also consult your doctor to help provide a more comprehensive and effective treatment for hay fever.

Quercetin Dosage for Covid-19
The FLCCC I-MASK+ protocol recommends 250 mg/day for COVID-19 prevention and 250 mg twice a day for treatment.

b. Astaxanthin Recommended Dose
Recommended dosages range from 4mg-12mg a day depending on the desired effect. 4mg daily has been shown to have positive effects reducing inflammation but up to 12mg a day provides more of a therapeutic dose for those in need of higher levels of antioxidants.

Astaxanthin is a fat-soluble carotenoid that should be consumed with a meal containing fat for optimal absorption.

10. Precaution


a. Who should not take quercetin?
Pregnant women, breastfeeding women, and people with kidney disease should avoid quercetin. Moreover, you should avoid higher doses than 1 g per day, there have been reports of damage to the kidneys. (Source)

Quercetin Interactions | Quercetin may interact with a number of medications..
– Antibiotics: May prevent the action of antibiotics
– Blood thinners: Could increase the effects of blood-thinning medication
– Chemotherapy: May interact with chemotherapeutic medication
– Corticosteroids: Could cause these medications to stay in your body for longer
– Cyclosporine: May interact with the absorption of this medicine
– Digoxin: Could increase the risk of side-effects associated with this chemical agent
– Fluoroquinolones: May decrease the effectiveness of these medicines
– Medications altered/activated by the liver: Quercetin may change how your body metabolizes medicine that is activated in the liver

b. Who should not take Astaxanthin?
Before taking Astaxanthin best to talk with your doctor if you are allergic to it or you currently taking other medications related to it. The product may cause serious allergic reactions.

It is used with caution for people with bleeding disorders, diabetes, autoimmune disorders, hypertension, low blood calcium levels or parathyroid disorders, allergy to 5-alpha-reductase inhibitors or asthma.