NMN vs NR: What's the Difference?
What is the difference between NMN and NR? Due to the small alphabetical difference, these supplements are often mixed up and confused by most consumers. We will cover the essentials and explain about each of these supplements below.
1. Eco Cert NMN Plus
2. Double Wood NMN Supplement
3. Toniiq NMN Powder
4. NMN Max NAD+ Booster Supplements
Why Choose Sublingual NMN Lozenges?
5. Livemax NMN Supplement
6. Komprocha NMN + Trans-Resveratrol
7. ChriBubble NMN Stabilized Form Supplement
8. Vitablossom NMN Supplement
Nicotinamide mononucleotide or NMN, a molecule naturally occurring in all life forms. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells.
Of all the NAD+ boosters – compounds which either convert directly into, or contribute in some way to the process of creating NAD+, nicotinamide riboside (NR) has been the most extensively studied – mostly in animals.
In rodent studies NR has been shown to have a variety of different effects desirable for different people looking for different things. In one study, mice who were fed a diet high in both sugar and fat in order to quickly create obesity, gained less body fat and demonstrated increased insulin sensitivity when taking an orally-administered dose of NR.
Mice receiving the same size dose of NR as the obesity study (400mg per kilo of bodyweight) were also found in another study to have reversed mitochondrial damage and increased mitochondrial biogenesis, the process through which mitochondria are created.
Finally, neurological benefits from NR supplementation were also confirmed in rodents, including neurogenesis, synaptic plasticity, and reduced beta-amyloid build up in the brain, a strong indicator of Alzheimer’s risk.
“Whether taking nicotinamide riboside will have the same effects on delaying aging or improving mitochondrial function in humans as it does in animals is unknown,”writes famed longevity expert Dr. Rhonda Patrick on her blog.
“However, when people with type 2 diabetes took a nicotinic acid derivative (an NAD+ precursor), they exhibited improvements in mitochondrial function in their skeletal muscle as well as increased NAD+ levels in their muscles”.
While most anti-aging products try to reverse signs of aging on your skin, nicotinamide riboside — also called niagen — aims to reverse signs of aging from inside your body.
There are multiple precursors to NAD+, each with its own physiologic effects. Nicotinamide riboside (NR) is a popular one with several notable benefits over other precursors like niacin (NA) and niacinamide (NAM). NA, for instance, may induce uncomfortable flushing, while NAM may inhibit sirtuin at high doses, both undesirable effects.
Nicotinamide riboside, or niagen, is an alternative form of vitamin B3, also called niacin.
Like other forms of vitamin B3, nicotinamide riboside is converted by your body into nicotinamide adenine dinucleotide (NAD+), a coenzyme or helper molecule.
Nicotinamide riboside supplements — such as niagen — have quickly become popular because they appear to be especially effective at raising NAD+ levels (Trusted Source). Nicotinamide riboside is also found in trace amounts in cows’ milk, yeast and beer (Trusted Source).