NMN vs NR: What's the Difference?

What is the difference between NMN and NR? Due to the small alphabetical difference, these supplements are often mixed up and confused by most consumers. We will cover the essentials and explain about each of these supplements below.

 

What Does NMN Supplement Do?

 
In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Here, we look at the science behind NMN, its stability, possible pharmacokinetics, transport, function, and ability to induce biosynthesis of NAD+. Supplementing NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions.
 
 

Is Nicotinamide Riboside same as NMN?

 
The molecular structures of NMN and NR are roughly the same, except NMN has an added phosphate group. This added phosphate group makes NMN a larger molecule than NR. 
 
NMN converts to NAD+ whereas NR must first be converted into NMN before it can be converted into NAD+, so it makes more sense to use NMN for NAD+ augmentation instead of NR.
 
 

Is NR Better Than NMN?

 
Currently, scientific evidence seems to suggest that NMN is better than NR because NMN is further down the NAD+ production pathway. Molecularly speaking, NMN looks more like NAD+ than NR does. Additionally, studies show impressive results of NMN on many aging mechanisms, more so than NR.
 

1. Eco Cert NMN Plus

 

 

– Naturally, Boost NAD+ Levels for Mental Performance & Anti Aging Supplement
 
– BOOST NAD+ LEVELS. Each time you take NMNPLUS, it will help replenish your body’s NAD.
 
– FULLY STABILIZED & ENHANCED ABSORPTION: Our NMN comes in a completely shelf-stable non-refrigerated form and is packaged and sold in opaque bottles and desiccant packs to protect it from light and moisture. 
 
– Unique ENTERIC CAPSULE to highly reduce unnecessary component loss and ensure maximum absorption of NMN.
 
– SLOWS AGING PROCESS. It can provide cellular energy optimization & health span support to enhance body functions and reduce disease risk. 
 
– Improves mood, support mental performance, and fight cognitive decline. 
 
– Take ONE capsule per day with food or a glass of water as you like. 
 
– Suitable for vegetarians and vegans, without traces of animal products. No GMO or Preservatives, No Artificial Color, No Flavor or Sweetener, No Sugar, No Starch, No Milk, No Corn, No Soy, No Wheat, No Tree Nut, No Peanut, No Egg, No Lactose, No Gluten, No Yeast, No Fish, No Shellfish, No Sodium.
 
Review
I loved the way it’s making me feel, I don’t feel sluggish and tired, I believe it’s replaced vitamins my body was lacking. I don’t eat many greens in my daily diet, and this definitely made my body improve. Because I felt more energetic I also moved around a lot more and felt like maybe I was losing some weight, I really like that I don’t get any nasty taste when burping either. It’s as if I didn’t take anything. I enjoy your products very much.
 
Ratings
4.5 out of 5 – 824 global ratings

2. Double Wood NMN Supplement

 

 

– 60 capsules, 1 month supply
– Increases NAD+ Levels
– Normally NMN is to be kept refrigerated due to its short shelf life however our NMN is fully stabilized to not need refrigeration. Our process of stabilization ensures that the NMN does not deactivate before it reaches your cells.
– Made in the USA
– GMO-Free 
 
Review
I’ve been using resveratrol (Jeuness) for 3.5 years, resveratrol was discovered by Dr David Sinclair (Harvard Medical School) discovered in 1992. No longer get cold. However, I’m still get tired due to aging, I believe. And getting worse lately when I’ve been working hard. So I started looking and noticed Dr Sinclair’s book titled Lifespan: Why We Age—and Why We Don’t Have To. From which I learned NMN. Then I ordered 1 bottle of NMN (Underwood). I take 4 capsules per day. Label says you can take 2-8 pills. The first week I felt less tired, but wasn’t so sure it is due to NMN or something else. The second week, I started running instead of walking, so even I’m shocked! I haven’t felt so hungary and energetic for the past decade! So it has to be NMN that worked!!
While I continue using resveratrol at the same time, I feel NMN makes you feel much more energetic. Can’t comment longevity yet, but possible, even with NMN.
 
Ratings
4.6 out of 5 – 1,264 global ratings

3. Toniiq NMN Powder

 

 

– Boost NAD+ Levels – Nicotinamide Mononucleotide Powder Supplement
 
– Highly Purified Form of NMN Powder 
– Our NMN powder contains an unprecedented purity level of 99+% (other NMN supplements and NAD supplement products won’t disclose their purity levels).
– Fully Stabilized – NMN typically needs to be kept cold (fridge or freezer) because of its short shelf life. Our NMN formula comes in a completely shelf-stable non-refrigerated form and is packaged and sold in black sealed bottles that block light, moisture, and oxygen to ensure maintained and maximum potency.
– Toniiq products are produced in a GMP-certified and NSF-approved state-of-the-art manufacturing facility right here in the USA.
– We test each batch both ourselves and through a third-party independent laboratory to ensure our ingredients contain the correct standardized level of purity and active ingredients. We also test each batch for any possible additives, contaminants, and impurities to ensure the highest level of quality.
 
Review
I have been using Toniiq NMN along with Resveratrol for about 7 and a half months now. I started taking these for longevity purposes after reading about them in Lifespan. Unexpectedly, I started to see my male pattern baldness reversing about 4 months in; I was not expecting this. Based on the regrowth process speed, it appears I’ll reverse 8 years of hair loss in less than a year! My barber is totally floored that hair follicles can come back to life. I can only assume the cells in the rest of my body are rejuvenating as well.
 
I had been taking the NMN in pill form, but the powder seems to be a much better value. It has a slight tart flavor which I actually enjoy. I’ve only been using this new form for a short time, but I expect to continue to see the same results.
 
Ratings
4.6 out of 5 – 295 global ratings

4. NMN Max NAD+ Booster Supplements

 

 

-120 Tablets / 500 mg each Tablet/ 4 Months Supply
– Can be chewed or used sublingually (under the tongue). 
– Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that is known to promote health and longevity by serving as a precursor to NAD+. NAD+ is required for our longevity genes to work. 
– NMN Boosts Energy Metabolism; Promotes Healthy Brain Function; Anti-Aging & DNA Repair.
– NON-GMO, GLUTEN-FREE, VEGAN FRIENDLY 
– Made without any chemical solvents, artificial ingredients, colors, preservatives or additives.
– Lozenges allow NMN to be absorbed directly into the blood vessels in the mouth and under the tongue, which can greatly increase the bioavailability of NMN and enhance the absorption of NMN in the blood.
 
Why Choose Sublingual NMN Lozenges?
* NMN Mood Enhancer, NMN Help Weight Loss, NMN Boost NAD+ Level, NMN Energize Your Body, Enhance Immune System, NMN Promote Anti-Aging, NMN Improve Sleep Quality, Optimize Energy Metabolism, Support Cardiovascular Health
 
Review
I’ve been taking NMN for about six months. I can feel the difference – I have more energy, and when I exercise I build more muscle mass.
 
Ratings
4.8 out of 5 – 180 global ratings

5. Livemax NMN Supplement

 

 

MAX STRENGTH NMN CONTENT. LIVEMAX capsules give you what other Nicotinamide Mononucleotide supplement can’t—one of the highest potencies of lab-tested NMN extract on the market.
 
ANTI-AGING POWERHOUSE. LIVEMAX are your wellness butler, working to support metabolism, increase your body’s NAD level and make you full of energy. NMN is world famous for its anti-aging power, supporting your immune system year-round.
 
BEST VALUE FOR MONEY. Not only do we offer a high potency formula, each bottle contains 60 capsules, making it one of the best value NMN supplements available. With more capsules per bottle and superior potency per capsule, LIVEMAX is great value for money.
 
SAFE, PRECIOUS INGREDIENTS. We use only the highest-quality ingredients. Plus, we test everything at our lab, so you can be confident that you’re fueling your body with the very best.
 
– Each bottle contains 60 capsules, serving size one capsule a day
 
Review
I started taking this product several months ago as both a boost to my overall health and to improve my blood sugar and blood pressure. I’m happy to say that my last physical showed that I’m doing very well.This product appears to be high-quality, and I plan to continue taking it on a daily basis into the foreseeable future.
 
Ratings
4.7 out of 5 – 587 global ratings

6. Komprocha NMN + Trans-Resveratrol

 

 

– Powerful Antioxidant & Anti-Aging Supplements for Heart, Immune & Skin Health
 
– Trans-Resveratrol (600mg) + NMN(500mg) +Black Pepper Extract (50mg)
– 60 capsules (Two daily)
 
– Komprocha NMN Trans-Resveratrol increases activity of the sirtuins – SIRT1 and SIRT3, in particular. In some study, resveratrol was shown to be the most potent natural activator of the sirtuins proteins. It has a positive effect on all three major longevity pathways.
 
– NMN nicotinamide mononucleotide is the direct precursor of NAD+ molecules, repair DNA and generate cell energy. 
– Taking NMN supplement will help to replenish NAD in the body. 
– Black pepper extract can effectively increase the bioavailability and increase the absorption rate of the main components. Enhanced absorption to slowing resveratrol breakdown.
 
– Third party lab tested for Trans-Resveratrol purity. And Our NMN Resveratrol Capsules comes in a completely shelf-stable non-refrigerated form, And the unique ENTERIC CAPSULE to highly reduce unnecessary component loss and ensure maximum absorption of NMN Resveratrol.
 
52 year old active male with weight lifting regularly for 20 years. My wife is 50. Day 3 and I started having flights of creative thought and exponential energy. My Focus was so strong I no longer needed breaks to keep going. Take in the morning on a empty stomach. Any drag by afternoon take an additional. I can only assume a complete cell reversal in 30 days for a healthier overall look.
 
My wife had been dealing with anxiety and it’s all gone. This might be one of the most significant additions to a health regiment.
 
If you are a male over 40 supplement with DHEA 50 – 100mg a day. DHEA is a precursor to testosterone. Combine NMN and those 2 for the ultimate feel good combo. I am lost for words on this breakthrough supplement.
 
Ratings
4.8 out of 5 – 280 global ratings

7. ChriBubble NMN Stabilized Form Supplement

 

 

– Supports NAD, Longevity & Energy, 500mg Per Serving
– Chribubble NMN supplement helps to defend your cells’ health & boost NAD+ levels to optimal levels to provide you with the added energy you need to power through the day ,say goodbye to those groggy days.
– Take one Chribubble nmn 500mg capsule daily
– Anti-Aging Support Supplement, our NMN shows great power to SLOW THE AGING PROCESS. Provide cellular energy optimization & health span support to enhance body functions and reduce disease risk. 
– And our NMN supplement can help promote a positive mood, support mental performance, and fight cognitive decline. 
 
Review
Been on a strict vitamin regimen for years and recently added NMN after a friends recommendation. I have noticed increased focus and higher energy since addition and plan to keep in the lineup, my wife will be adding to hers. Great nmn.
 
Ratings
4.8 out of 5 – 317 global ratings

8. Vitablossom NMN Supplement

 

 

– 500mg, 60 Capsules Per Bottle
– NMN Nicotinamide Mononucleotide NAD Supplements
– Boost NAD Levels for Anti Aging, Energy Supplement, Cellular Repair & Healthy
– Non GMO
– VEGAN Friendly
– No Artificial Flavors and Color Added
– No Binders
– Gluten Free
 
Review
Day 15 of taking these nmn supplement and I’ve already noticed a difference with increased energy levels and feeling more alert.
 
Ratings
4.7 out of 5 – 368 global ratings

FAQs

Nicotinamide mononucleotide or NMN, a molecule naturally occurring in all life forms. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells.

NMN is a precursor to NAD+, or nicotinamide adenine dinucleotide, meaning it becomes NAD+ through a series of chemical transformations. NAD+ is a critical found in every cell of your body, but levels of NAD+ naturally fall with age, making it — and NMN, as a result — crucial.
 
However, NMN is like a large bed that movers are trying to get through a door: It doesn’t enter the cell easily. One way for NMN to enter the cell is for it to chemically transform into another molecule (called nicotinamide riboside, or NR) before it can enter the cell. NR has earned a name for itself as a highly efficient precursor to NAD+ and can enter the cell as is. NMN, meanwhile, sometimes becomes NR before entering the cell, where it chemically transforms back to NMN and then ultimately becomes NAD+.
 
We’ve learned that NR leads to NAD+ and that it also has its own pathway that bypasses various steps other NAD+ precursors have to take. In early 2019, though, new research revealed NMN might only have to become NR for certain cell types, as NMN can enter cells in the small intestine of mice. It’s unclear whether or how this will translate to humans, if at all, but it’s teed up NMN as the newer kid on the block, making many wonder: How does it stack up against NR?
 
 

Of all the NAD+ boosters – compounds which either convert directly into, or contribute in some way to the process of creating NAD+, nicotinamide riboside (NR) has been the most extensively studied – mostly in animals.

In rodent studies NR has been shown to have a variety of different effects desirable for different people looking for different things. In one study, mice who were fed a diet high in both sugar and fat in order to quickly create obesity, gained less body fat and demonstrated increased insulin sensitivity when taking an orally-administered dose of NR.

Mice receiving the same size dose of NR as the obesity study (400mg per kilo of bodyweight) were also found in another study to have reversed mitochondrial damage and increased mitochondrial biogenesis, the process through which mitochondria are created.

Finally, neurological benefits from NR supplementation were also confirmed in rodents, including neurogenesis, synaptic plasticity, and reduced beta-amyloid build up in the brain, a strong indicator of Alzheimer’s risk.

“Whether taking nicotinamide riboside will have the same effects on delaying aging or improving mitochondrial function in humans as it does in animals is unknown,”writes famed longevity expert Dr. Rhonda Patrick on her blog.

“However, when people with type 2 diabetes took a nicotinic acid derivative (an NAD+ precursor), they exhibited improvements in mitochondrial function in their skeletal muscle as well as increased NAD+ levels in their muscles”.

Pitting NR and NMN against each other is, for now, somewhat of a moot point because the two molecules have never been studied side by side in humans. The biggest, and most obvious, difference between NMN and NR is size. NMN is simply larger than NR, meaning it often needs to be broken down to fit into the cell. NR, when compared to other NAD+ precursors (like nicotinic acid or nicotinamide) reigns supreme in efficiency.
 
But give NMN a new door, one it can fit through, and it’s a whole new game. This is where cellular transporters come into play. Transporters are proteins that are doors on the cell; they allow molecules to enter the cell without needing to chemically transform.
 
The latest research from Shin-ichiro Imai, M.D., Ph.D., a professor of developmental biology at Washington University in St. Louis, identified a transporter that allows NMN to get into the cell without converting to NR. The catch? The transporter is only on cells located in the gut of mice and only works in the presence of sodium ions. NR, however, has been shown to enter cells in the liver, muscle, and brain tissue of mouse models. (To date there is not yet evidence that these mouse studies can be extrapolated to humans) But again, the two have never been matched up against each other in a way that can truly identify one as superior to the other.

While most anti-aging products try to reverse signs of aging on your skin, nicotinamide riboside — also called niagen — aims to reverse signs of aging from inside your body.

There are multiple precursors to NAD+, each with its own physiologic effects. Nicotinamide riboside (NR) is a popular one with several notable benefits over other precursors like niacin (NA) and niacinamide (NAM). NA, for instance, may induce uncomfortable flushing, while NAM may inhibit sirtuin at high doses, both undesirable effects.

 
Because of its unique profile of benefits and low risks, NR has emerged as a popular choice, especially by its discoverer, biochemist Charles Brenner, among the NAD+ precursors. In Scientific Reports, researchers noted:
 
“Because NR does not cause flushing or inhibit sirtuins and the genes (NRK1 and NRK2) required for the metabolism of NR to NAD+ are upregulated in conditions of metabolic stress, NR has a particularly strong potential as a distinct vitamin B3 to support human wellness during metabolic stress and aging.”
“Therefore, administration of niacin or niacinamide is unlikely to be widely adopted for maintaining health and function with aging,” researchers wrote in Nature Communications.
Within your body, nicotinamide riboside is converted into NAD+, a helper molecule that exists inside each of your cells and supports many aspects of healthy aging.
 
Nicotinamide riboside, or niagen, is an alternative form of vitamin B3, also called niacin.

Like other forms of vitamin B3, nicotinamide riboside is converted by your body into nicotinamide adenine dinucleotide (NAD+), a coenzyme or helper molecule.

Nicotinamide riboside supplements — such as niagen — have quickly become popular because they appear to be especially effective at raising NAD+ levels (Trusted Source). Nicotinamide riboside is also found in trace amounts in cows’ milk, yeast and beer (Trusted Source).

 
NR used to be considered superior because no NMN transporter — required to get it into cells — had been detected. We now know there is such a transporter, which gives NMN the advantage as it’s also a more direct NAD+ precursor.
 
Most of the NAD+ precursor research is done with NR. However, as you can see from the image above, NMN converts to NAD+ whereas NR must first be converted into NMN before it can be converted into NAD+, so it makes more sense to use NMN for NAD+ augmentation.
The image above also shows how niacin (NA) also finds its way to become NAD+. Niacin is also a useful supplement to use in increasing NAD+ levels. You just need to limit the dose to about 25 mg, which most is a dose low enough not to cause any flushing. Higher doses are not likely as effective as NMN and exercise in producing NAD+.
NMN can be found naturally in broccoli, cabbage, cucumber, edamame and avocado.
 
case series (published in September 2020) of 9 elderly COVID-19 patients treated with a combination of NMN, zinc, betaine and sodium chloride resulted in rapid improvement.