Best Vitamin D3 Supplements For Acne 2022

Vitamin D is a fat-soluble vitamin, which means it dissolves in fats and oils and can be kept for a long period in your body. Vitamin D is essential to the body in many ways. It helps the body absorb calcium from food and supplements. Muscles need it to move, for example, nerves need it to carry messages between the brain and every body part, and the immune system needs vitamin D to fight off invading bacteria and viruses. Together with calcium, vitamin D also helps protect older adults from osteoporosis. Apart from its role in maintaining bone health, vitamin D also has a role in maintaining skin health. 

Vitamin D for Acne

Acne is a common and complex skin disorder that can be stressful for many patients due to its chronicity. Although acne is caused by a number of factors, but chronic inflammation is an important mechanism.


According to a study, vitamin D has an immune regulatory function in sebocytes, implying that vitamin D may have anti-inflammatory properties in acne patients.

Best Vitamin D3 Supplements For Skin

1. Garden of Life Vitamin D3 2000 IU

Garden of Life Vitamin D, Vitamin Code Raw D3, Vitamin D 2,000 IU, Raw Whole Food Vitamin D Supplements with Chlorella…

Dosage: 2000 IU (50 mcg) / softgel

Garden of Life Vitamin Code Raw D3 Price : $17.04 (60 Counts)

#8 Best Sellers in Vitamin D Supplements on Amazon

The only RAW, whole food, vegetarian Vitamin D3 delivered in a whole food lipid base of high Omega-9, Organic Green Cracked Wall Chlorella – plus live probiotics and enzymes for optimal absorption and digestion. Our Vitamin Code Raw D3 is whole food nutrition, specifically formulated with 2,000 IU of Vitamin D3, which provides bone and joint support, colon and digestive support, memory & concentration, breast & prostate health, proper cell replication and immune system support.


In addition, this D3 vitamin is Non-GMO, RAW, Vegetarian, Gluten Free, Dairy Free and Kosher, with No Binders or Fillers.


4.8 out of 5 – 10,194 global ratings.
When my D test results came up with a 23 more than a year ago, my doc told me to supplement. She didn’t want to prescribe because the prescription is a mega dose that’s hard on stomachs, so we tried supplements first. I tried another popular brand, and in the ensuing year, my D level dropped from D to 17. Doc suggested switching brands before going to the prescription, so I tried this one, and the test result jumped from 17 to 25 in three months!

2. Nature Made Extra Strength Vitamin D3 5000 IU

Nature Made Extra Strength Vitamin D3 5000 IU (125 mcg), Dietary Supplement for Immune Support, 90 Softgels, 90 Day…

Dosage: 5000 IU (125 mcg) / softgel

Nature Made Vitamin D3 5000 IU for Immune Support Price: $14.39 (90 Counts)

#2 Best Sellers in Vitamin D Supplements on Amazon

One 90 count bottle of Nature Made Extra Strength Vitamin D3 5000 IU (125 mcg) Softgels for a 90-day supply to help support immune health, aid in calcium absorption to support bone health and teeth health, and help support muscle function. For adults, one softgels daily with a meal, but for easier swallowing, take with water before and during ingestion.


Moreover, Gluten-free dietary supplements made with high-quality ingredients, these Vitamin D3 supplements have no added color or artificial flavors. These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease


4.8 out of 5 – 32,120 global ratings.

I work the midnight shift and I’m living a vampire lifestlye. The only sunlight I get is on my days off or driving home in the morning. This vitamin has definitely offset my deficiency. I noticed more of an energy.

3. Kirkland Signature 2000 IU

Kirkland Signature Maximum Strength Vitamin D3 2000 I.U. 600 Softgels, Bottle Personal Healthcare / Health Care

Dosage: 2000 IU (50 mcg) / softgel

Kirkland Signature Extra Strength Vitamin D3 Price: $13.40 (600 softgels)

Kirkland Signature Extra Strength can support bone and immune health. Their formula is free from artificial colors and artificial flavors. No preservatives added, no yeast / gluten and no llactose.

4.8 out of 5 – 4,592 global ratings.

Excellent value. My husband and I both need to take D-3, so this was a good value. Also love that it is tiny gel capsules rather than pills.

4. Life Extension Vitamin D3 5000 IU

Life Extension Vitamin D3 125mcg (5000 IU) – Supports Bone & Immune Health – Non-GMO, Gluten-Free, Once Daily – 60…

Dosage: 5000 IU (125 mcg) / softgel

Life Extension Vitamin D3  – Supports Bone & Immune Health Price: $9.75 (60 Softgels)

#44 Best Sellers in Vitamin D Supplements on Amazon


Sourced using only the finest raw ingredients with the purity and potency your body deserves. The majority of our products are non-GMO, gluten-free, and manufactured in the USA—and a Certificate of Analysis is available for every product we produce.

We suggest at least 125 mcg (5000 IU) vitamin D3 a day, which makes this formulation perfect for getting enough vitamin D.Vitamin D helps get calcium into your bone matrix—the lattice-like structure that gives your bones their strength and rigidity. Vitamin D is good for your brain too: healthy levels of vitamin D3 has been shown to correspond to better cognitive health scores as you age!

4.8 out of 5 – 4,784 global ratings.
My doctor regularly checks all my levels, twice a year, and noticed several levels were low. One of them was my Vitamin D3 level so he started me a on a regimen of vitamin supplements, this being one of them. He also suggested that not all vitamins are quality ones, and he recommended that I use Life Extension. My levels are back in the normal range. I’m very happy with the product.

5. Viva Naturals Vitamin D3 5000 IU

Vitamin D3 5000 IU (360 Softgels) - High Potency Vitamin D Supplements, Small Easy to Swallow Softgels & No Taste, Made…

Dosage: 5000 IU / softgel

Life Extension Vitamin D3  – Strong Bone* & Healthy Immune* Price: $13.99 (360 Softgels)

#98 Best Sellers in Vitamin D Supplements on Amazon


Helps Keep Vitamin D Levels at their Best* – For many of us, it can be hard to get enough vitamin D3 through sunlight and diet alone. Whether you’re avoiding direct sun exposure, or stuck inside through the dark winter months, it’s important to maintain optimal vitamin d levels.* Our Vitamin D3 contains 5000 IU of this essential vitamin. It’s the perfect option for people who have been identified as vitamin D3 deficient and recommended a higher dose supplement by their healthcare practitioner.*

Moreover, each bottle of our Vitamin D supplement contains a full year’s supply and only the best ingredients, with no artificial dyes or preservatives. Proudly made in the USA in GMP-compliant facilities with domestic and imported ingredients, our vit d3 5000 IU softgels are Non-GMO, Gluten-Free, Soy-Free and Third Party Tested.



4.8 out of 5 – 4,852 global ratings.
Even though I said in the title of this review that I am very satisfied with my purchase of this product–and I am, don’t get me wrong– I think that I should offer a word of warning to prospective buyers. This 5,000 iu product is a very strong concentration of Vitamin D3. I, personally, have medical conditions that render the concentrations of this vitamin to be very low in my blood. So, this product is good for me, but if your blood is of the more normal kind, be careful if you use this product. Your doctor should be regularly monitoring your blood to make sure that you are not overdosing yourself. But, other than that, I happy with the quality and the quantity of these gel caps.

6. Vitafusion Vitamin D3 Gummy 3000 IU

Vitafusion Extra Strength Vitamin D3 Gummy Vitamins, 120 ct

Dosage: 3000 IU (75 mcg) / gummy

Vitafusion Extra Strength Vitamin D3 Price: $31.50 (120 Gummies)

#14 Best Sellers in Vitamin D Supplements on Amazon

The Vitafusion Extra Strength line includes high potency Vitamin D3 fused into delicious gummies with Natural strawberry flavor. Vitamin D, also known as the “sunshine vitamin,” aids in the absorption of Calcium and Phosphorus which help to form and maintain strong bones and teeth. It may also play a role in maintaining strong muscles.* (These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.)

Moreover, this gummies contains NO high-fructose corn syrup, NO artificial sweeteners, NO gluten, NO dairy and NO synthetic (FD&C) dyes.


4.8 out of 5 – 9,061 global ratings.

I am very picky about the flavor of vitamins and medicine and these are delicious. They taste great and love that its extra strength too so get everything I need in one dose. Will buy again.

7. New Age Vitamin D3 5000 IU

Vitamin D3 5000 IU 125mcg Gummies by New Age - 2 Pack - Support Immune Health - Non-GMO, Gluten-Free, Dairy-Free, No Gelatin - 120 Count

Dosage: 5000 IU (125 mcg) / gummy

Vitamin D3 125mcg Gummies by New Age Price: $24.95 (2×60 Gummies)


New Age Vitamin D3 5000 IU per serving is a Vitamin D Gummy essential to keeping strong teeth, bones, muscles, joints, and immune system to improve daily health and wellness. Moreover, Each batch of New Age Gummies are third party tested to guarantee the highest purity, potency, and premium quality and also do not include any preservatives or artificial colorants


4.7 out of 5 – 1,643 global ratings.

Easy to chew, nice taste and easy to swallow. You only need 1 gummie, per day. No store near me ever carries 5000 IU Gummies, so I was very happy to find New Age Vitamins on Amazon! I highly recommend this product!

8. Carlyle Vitamin D3 2000 IU

Vitamin D3 2000 IU Softgels | 400 Count | Non-GMO, Gluten Free Formula | 50 mcg | Vitamin D Supplement | by Carlyle

Dosage: 2000 IU (50 mcg) / soft gel

Vitamin D3 2000 by Carlyle Price: $8.87 (400 Softgels)

Vitamin D3 can promotes strong bones and teeth* 

Carlyle’s high potency formula delivers 50 mcg of Vitamin D3 in a single softgel!

Our professional formula is backed by our commitment to purity and potency. Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed! Moreover, their formula is naturally free of Gluten, Wheat, Yeast, Lactose, Soy, Artificial Flavor & Sweetener & NON-GMO

4.8 out of 5 – 872 global ratings.

Not a horse pill and easy to swallow. I’ll be back again to buy more.

Frequently Asked Question

Vitamin D needs to undergo two conversion steps to become active (SourceSource).

First, it is converted to calcidiol, or 25(OH)D, in your liver. This is the storage form of the vitamin.

Second, it is converted to calcitriol, or 1,25(OH)2D, mostly in your kidneys. This is the active, steroid-hormone form of vitamin D.

Calcitriol interacts with the vitamin D receptor (VDR), which is found in almost every single cell in your body (Trusted SourceTrusted Source).

When the active form of vitamin D binds to this receptor, it turns genes on or off, leading to changes in your cells. This is similar to how most other steroid hormones work (Trusted SourceTrusted Source).

Vitamin D affects various cells related to bone health. For example, it promotes the absorption of calcium and phosphorus from your gut (Trusted Source).

But scientists have recently discovered that it also plays roles in other areas of health, such as immune function and protection against cancer (Source).
About Vitamin D supplements

Vitamin D3 supplements appear to be more effective at raising vitamin D levels than D2 supplements. 

Vitamin D ensures that your blood levels of calcium are high enough to meet your body’s demands. However, vitamin D does not fully control where the calcium in your body ends up. That’s where vitamin K steps in. Vitamin K2 supplements have been proven to be more effective than vitamin K1. That’s why most of the top vitamin D supplement brands do

Vitamin D is a fat-soluble vitamin, meaning that it does not dissolve in water and is absorbed best in your bloodstream when paired with high-fat foods.

For this reason, it’s recommended to take vitamin D supplements with a meal to enhance absorption.

According to one study in 17 people, taking vitamin D with the largest meal of the day increased vitamin D blood levels by about 50% after just 2–3 months (NIH).

In another study in 50 older adults, consuming vitamin D alongside a fat-heavy meal increased vitamin D blood levels by 32% after 12 hours compared to a fat-free meal (NIH).

Avocados, nuts, seeds, full-fat dairy products and eggs are nutritious sources of fat that help boost your vitamin D absorption.
There are two main dietary forms (NIH):
  • Vitamin D3 (cholecalciferol). Found in some animal foods, like fatty fish and egg yolks.
  • Vitamin D2 (ergocalciferol). Found in some plants, mushrooms, and yeasts.

Difference between vitamin D and D3? Of the two, D3 (cholecalciferol) seems to be almost twice as effective at increasing blood levels of vitamin D as D2 (ergocalciferol) (NIHNIH).

In the US, current guidelines suggest that consuming 400–800 IU (10–20 mcg) of vitamin D should meet the needs of 97–98% of all healthy people (Trusted Source).

However, many experts believe the guidelines are far too low (Trusted Source).

Your vitamin D needs depend on a variety of factors. These include your age, skin color, current blood vitamin D levels, location, sun exposure and more.

To reach blood levels linked to better health outcomes, many studies have shown that you need to consume more vitamin D than the guidelines recommend (Trusted SourceTrusted SourceTrusted Source).

For instance, an analysis of five studies examined the link between vitamin D blood levels and colorectal cancer (Trusted Source).

Scientists found that people with the highest blood levels of vitamin D (over 33 ng/ml or 82.4 nmol/l) had a 50% lower risk of colorectal cancer than people with the lowest levels of vitamin D (less than 12 ng/ml or 30 nmol/l).

Research also shows that consuming 1,000 IU (25 mcg) daily would help 50% of people reach a vitamin D blood level of 33 ng/ml (82.4 nmol/l). Consuming 2,000 IU (50 mcg) daily would help nearly everyone reach a blood level of 33 ng/ml (82.4 nmol/l) (Trusted SourceTrusted SourceTrusted Source).

According to Dr John Campbell:
  • Deficiency: Less than 20 ng/ml (50 nmol/L)
  • Insufficiency: 21 – 29 ng/ml (52 – 72 nmol/L)
  • Sufficiency: More than 30 ng/ml (75 nmol/L)

Another analysis of seventeen studies with over 300,000 people looked at the link between vitamin D intake and heart disease. Scientists found that taking 1,000 IU (25 mcg) of vitamin D daily reduced heart disease risk by 10% (Trusted Source).

Based on current research, it seems that consuming 1,000–4,000 IU (25–100 mcg) of vitamin D daily should be ideal for most people to reach healthy vitamin D blood levels.

However, don’t consume more than 4,000 IU of vitamin D without your doctor’s permission. It exceeds the safe upper limits of intake and is not linked to more health benefits (Trusted Source).

Vitamin D deficiency is one of the most common nutrient deficiencies.

Some people are at a greater risk than others. In the United States, 41.6% of the total population is deficient, although minorities fare worse — 82.1% and 69.2% of blacks and Hispanics are deficient, respectively (Trusted Source).

Additionally, older adults are at a much greater risk of being deficient (Trusted Source).

Those who have certain diseases are also very likely to be deficient. One study showed that 96% of people who had experienced heart attacks were low in vitamin D (Trusted Source).

Overall, vitamin D deficiency is a silent epidemic. The symptoms are usually subtle and may take years or decades to surface.


Symptom of vitamin D deficiency

The most well-known symptom of vitamin D deficiency is rickets, a bone disease common in children in developing countries.

Rickets has been mostly eliminated from Western countries because of the fortification of some foods with vitamin D (Trusted Source).

Deficiency is also linked to osteoporosis, reduced mineral density, and increased risk of falls and fractures in older adults.

What’s more, studies indicate that people with low vitamin D levels have a much greater risk of heart disease, diabetes (types 1 and 2), cancer, dementia, and autoimmune diseases like multiple sclerosis (Trusted Source).

Finally, vitamin D deficiency is linked to a reduced life expectancy (Trusted SourceTrusted SourceTrusted Source).

That said, it’s unclear whether deficiency contributes to these diseases or whether people with low levels are just more likely to get them.


Vitamin D is needed not only to keep bones healthy but also to maintain your immune system and skin health. Vitamin D deficiency can lead to a loss of bone density, which may result in osteoporosis and fractures (broken bones). Moreover, severe vitamin D deficiency can also lead to other diseases.


However, too much Vitamin D may also be dangerous to bone and kidneys. Therefore, it is important to know your Vitamin D level before taking any vitamin D supplements.


If you are unsure how much vitamin D3 you should take (or you’re concerned you’re taking too little or too much), there’s a blood test called a 25-hydroxy vitamin D blood test. Make sure to review your blood test results with your medical advisor.