Best Quercetin, Resveratrol and Curcumin Supplements 2022

Quercetin, resveratrol, and curcumin are plant-derived natural compounds that are becoming widely studied because of their apparent therapeutic potential. Those three are available as supplements for a wide assortment of conditions including cardiovascular disease, cancer, asthma, diabetes, and many more.

Moreover, according to experimental and limited clinical trial evidence, some polyphenols, such as quercetin, curcumin, and resveratrol, offer potential benefits in the treatment of obesity. (Source)

In this article, we will explain quercetin, resveratrol, and curcumin one by one so that you can understand the benefits of each nutrient. This should help you decide whether you want to take them all. Or maybe only one or two of them!

Quercetin

1. What is Quercetin?

quercetin
Quercetin, a flavonoid found in fruits and vegetables, including red wine, onions, green tea, apples, and berries.

a. Quercetin Benefits
Quercetin has an antioxidant effect, which may protect your cells from free radicals, which can cause heart disease, cancer, and other diseases.

Quercetin was also reported as a long lasting anti-inflammatory substance that possesses strong anti-inflammatory capacities. (Source)

Quercetin is typically used to treat heart and blood vessel disorders, as well as to prevent cancer. It is also claimed to treat arthritis, bladder infections, and diabetes, but there is little scientific evidence to back up the majority of these claims.

b. Quercetin Dosage
Quercetin supplement has typical dosages range from 500-1000 mg. You can take it by mouth daily for up to 12 weeks. But still, speak with your doctor to determine how much dose might be best for you, especially if you have a specific condition.

c. Quercetin Bioavailability

Quercetin bioavailability varies widely between individuals. But since Quercetin is not soluble in water, however, so it is a poorly absorbed nutrient. Bromelain, a protein-digesting enzyme extracted from pineapples, may boost quercetin absorption, as does vitamin C. Therefore, quercetin is often offered in combination with one or both additives.

d. Quercetin Food Sources
Apples, honey, raspberries, onions, red grapes, cherries, citrus fruits, and green leafy vegetables are high in quercetin. However, Onions have the greatest quercetin content of any vegetable or fruit.

e. Quercetin FAQ

When taken orally, quercetin may be safe for most people when used for a short period of time. Quercetin has been used safely in doses of up to 1 gram per day for 12 weeks. However, it is still unknown whether long-term use or greater doses are safe.

Quercetin is generally recognized as safe. It’s found in many fruits and vegetables, and most people will experience no side effects when taking normal dosages of quercetin.

There have been few reported side effects for quercetin supplements.
In some studies, large doses of quercetin (over 1,000mg) were linked with headaches, digestive issues, and tingling sensations.

There’s no evidence that quercetin interacts with any drugs in a significant way. However, you should talk to your doctor before taking quercetin, especially if you are taking antibiotics or blood pressure medication.

Due to its anti-oxidant, anti-tumor and anti-inflammatory activity, quercetin has been studied extensively as a chemoprevention agent in several cancer models []. Quercetin has been shown to inhibit the proliferation of a wide range of cancers such as prostate, cervical, lung, breast, and colon. (Source)

Quercetin is generally thought to be safe. Headache and stomach distress are possible side effects. Preliminary research suggests that a byproduct of quercetin can cause protein function to be lost. High dosages of quercetin may cause kidney damage. You should take periodic breaks from taking quercetin. 

 

Best to determine the best dose of quercetin qith your doctor.

2. Best Quercetin Supplements

a. Quercetin – Amazing Formulas Quercetin

 

b.  Quercetin with Bromelain – Now Foods Quercetin with Bromelain

Now Foods Quercetin supplements contain Bromelain, as some evidence suggests they boost absorption.

 

c. Quercetin with Vitamin C and Zinc – Whole Foods Quercetin Plus

Contains Bromelain, Zinc, Vitamin C and Ginger-Bioflavonoids. This supplement provides support for the immune, cardiovascular and respiratory system. Quercetin with vitamin C and zinc is proven not only to provide immune support but also to improve metabolism, circulatory supporty, and cognitive clarity.
 
Quercetin with Bromelain, Stinging Nettle and Vitamiin C may help with sinus relief, allergies, cardiovascular and respiratory health. 
 
This organic Quercetin extract product is the supermix capsules, includes Quercetin, Turmeric Curcumin, Berberine, Stinging Nettle, Black Seed powder, Black Pepper and is suitable for vegans.

Resveratrol

3. What is Resveratrol?

resveratrol food sources

Resveratrol is a class of plant micronutrients called polyphenols. It is a well known biologically active compound synthesized by plants undergoing infectious or ionizing radiation. (Source)

a. Resveratrol Benefits
Resveratrol contains antioxidant and anti-inflammatory effects that can protect you from diseases such as cancer, diabetes, and Alzheimer’s.

Resveratrol’s anti-inflammatory properties make it an effective treatment for arthritis and skin inflammation. In addition, resveratrol contains antibacterial and antifungal effects that aid in the treatment of urinary and digestive system infections.

A study provide new insight into the mechanism underlying anticancer efficacy of resveratrol and help the utilization of resveratrol as a novel agent for the treatment of ovarian cancer.

b. Resveratrol Dosage
Evidence from clinical studies is insufficient to provide dosing guidelines. Single-dose studies suggest that resveratrol 450 mg/day is a safe daily dose for a 70 kg person. Dosages more than 1 g/day tend to be well tolerated in the short term (2-week).(Source)

Low doses resveratrol protect health from different types of diseases, while high doses resveratrol can be detrimental for health. However, high dose resveratrol may be required in pathological conditions such as destroying cancer cells. (Source)

Best to determine the best dose with your doctor, especially if you have a specific condition.

c. Resveratrol Bioavailability
Trans-resveratrol concentrations of 98 percent or more are considered pure. According to research, both cis-resveratrol and trans-resveratrol are available in natural sources, however trans-resveratrol is more prevalent due to its bioavailability and stability.

Additions to pure trans-resveratrol supplements, such as quercetin, red wine extract, green tea extract, and BioPerine® have been shown to improve absorption. (Source)

d. Resveratrol Foods
You can find resveratrol in foods such as peanuts, pistachios, grapes, red and white wine, blueberries, cranberries, and even cocoa and dark chocolate.

e. Resveratrol FAQ

Short-term dosages of resveratrol do not appear to have any side effects (1.0 g). Otherwise, unpleasant effects such as nausea, vomiting, diarrhea, and liver dysfunction may occur at dosages of 2.5 g or more per day in patients with non-alcoholic fatty liver disease. (Source)

A study demonstrated that resveratrol intake significantly reduced weight, BMI, WC and fat mass, and significantly increased lean mass, however it did not affect leptin and adiponectin levels. (Source)

4. Best Resveratrol Supplements

a. Resveratrol with red wine extract – NOW Supplements, Natural Resveratrol 200 mg with Red Wine Extract

Easy way to benefit from the polyphenols naturally found in grapes and wine without imbibing.


b. Resveratrol with green tea extract and Vitamin C – PURELY beneficial Resveratrol

Resveratrol Blend made with Trans-Resveratrol, Green Tea Extract, Grape Seed Extract, Vitamin C, Acai Extract, Pomegranate Extract, Blueberry Extract, and More


c. Resveratrol with BioPerine® – Genex Formulas Resveratrol 1500mg Extra Strength*

Studies show that BioPerine can increase resveratrol absorption.


d. Resveratrol with Quercetin, Green Tea and Red Wine Extract – Purest Vantage Resveratrol

Trans-resveratrol added with green tea extract, grape seed extract, acai fruit extract, quercetin and red wine extract. Combination to form one of the most potent antioxidant supplements available.

Curcumin

5. What is Curcumin?

curcumin

Turmeric, a spice long known for its therapeutic benefits, has caught the interest of medical world because it is the primary source of the polyphenol curcumin.

a. Curcumin Benefits
Curcumin has been shown to aid in the treatment of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and subsequent performance in active people. (Source). Furthermore, a low dose can provide health benefits to persons who do not have documented health concerns.

b. Curcumin Dosage
Curcumin is primarily available in capsule form from commercial manufacturers. The most common regimen is one to three 500 mg capsules daily with or without food. In one study, patients took one 500 mg capsule twice daily with or without food for 8 weeks for treatment of major depressive disorder. (Source)

However, Higher doses are associated with adverse side effects. Best to talk to your doctor to determine the best dose for you, especially for someone who has a specific condition or undergo treatment.

c. Curcumin Bioavailability
Curcumin has multiple health benefits, which appear to act primarily through its anti-oxidant and anti-inflammatory mechanisms. These benefits are best achieved when curcumin is combined with agents such as piperine, which increase its bioavailability significantly. (Source)

d. Curcumin Food Sources
Turmeric is the plant with the largest amount of curcumin. Turmeric is commonly sold in grocery shops as a ground spice as well as by the root. Turmeric is also used as a food color and can be found in foods such as mustard and butter to deepen the yellow color.

e. FAQ

High doses of turmeric and curcumin are not recommended long-term since research confirming their safety is lacking.

 

However, WHO has determined 1.4 mg per pound (0–3 mg/kg) of body weight an acceptable daily intake (Source).

 

Above all, always notify your doctor if you want to take this supplement.

Turmeric is generally considered to be safe. However,  It can cause nausea and diarrhea, especially when used in large dosages or over an extended period of time. In excessive doses, it may potentially increase the risk of ulcers. 

6. Best Curcumin Supplements

a. Curcumin with BioPerine Black Pepper Extract – NatureWise Organic Curcumin Turmeric 2250mg, 95 Curcuminoids

Curcumin by itself is poorly absorbed by the body. This turmeric with black pepper capsules are enhanced with ginger and Bioperine, a patented black pepper extract proven to dramatically increase bioavailability.


b. Curcumin Elite Turmeric Extract – Life Extension Curcumin Elite Turmeric Extract

This supplement combined curcumin from turmeric, a spice steeped in Ayurvedic tradition, with fibers from fenugreek seeds. This formula offers more bioavailable free curcuminoids and better absorption of total curcuminoids than standard curcumin.

2 in 1 : Resveratrol and Curcumin 

7. Curcumin and Resveratrol Together

Curcumin and resveratrol share anticancer properties, in which they exert synergistic effects. 
 
This research paper also concluded that both supplements showed greater anticancer properties when used together. It showed that the synergy between them inhibited colon cancer.
 
Curcumin and Resveratrol have also shown anti-inflammatory properties, especially in the case of acute inflammation in the small intestine. This study has explored the anti-inflammatory synergy between resveratrol and curcumin and found that they can reduce inflammation quite significantly.
 
Taking resveratrol with curcumin also enhances the health benefits of both supplements by boosting their antioxidative effects.
 

3 in 1 : Quercetin, Resveratrol and Curcumin 

Quercetin, Resveratrol and Curcumin may provide substantial therapeutic benefit especially in aging and chronic inflammatory diseases. This study suggests that delivering these compounds in combination may improve the acute bioavailability of Curcumin and Resveratrol compared to supplementation with single compounds, allowing for lower overall doses and simpler treatment protocols using combination therapies.
 
The combination of Quercetin, Resveratrol and Curcumin may improve intestinal absorption of Resveratrol and Curcumin without affecting Quercetin absorption. 

8. Ortho Nutrition Antioxidant Boost – Curcumin + Resveratrol + Quercetin

 

Curcumin and Resveratrol may share an interesting synergistic benefit, while Sulforaphane provides a welcome addition as an indirect antioxidant. Resveratrol, well-known for being a healthy direct antioxidant found in red wine, is a naturally-occurring flavonoid found in apples, grapes, and onions. 
 
Quercetin, another potent direct antioxidant found in apples, is considered to be an adrenal balancer while recent research suggests that it may also reduce stress hormone levels such as cortisol. Together, these antioxidants provide a strong anti-aging defense against free radical damage.
 
– Contains Trans-Resveratrol 99%, Curcumin 95%, Quercetin 95%, Sulforaphane Glucosinolate 2%
– Promotes life extension and liver health via anti-inflammatory signals & sirt1 caloric restriction
– Direct and indirect antioxidant activity to assist in the neutralization of free radical damage
– Boosts glutathione levels; Promotes anti-aging & anti-oxidant count within cells as nrf2-activator
– Gluten-free, Vegan-friendly & Non-GMO. Hypoallergenic. Contains no artificial fillers.