Best Natural Antioxidant Supplements for Inflammation 2022

Inflammation is the body’s response to harmful stimulus such as injury, infection, or irritation. There are two main types of inflammation ; acute inflammation and chronic inflammation.
Acute inflammation usually restores your body to its state before injury or illness. It often resolves in two weeks or less. Symptoms appear quickly. 
Chronic inflammation slower and generally less severe form. It typically lasts longer than six weeks. It can occur even when there’s no injury, and it doesn’t always end when the illness or injury is healed. Chronic inflammation has been linked to autoimmune disorders and even prolonged stress.
– Redness
– Heat
– Swelling
– Pain
– Loss of function: Not able to move the injured part easily
– Anti-Inflammatory Diet

Researchers have identified certain foods that can help control inflammation. Many of them are found in the so-called Mediterranean diet, which emphasizes fish, vegetables and olive oil, among other staples.

There’s a standardized research tool that’s updated regularly that allows anybody to see if they’re eating foods we know cause chronic inflammation. This is called the The Dietary Inflammatory Index or DII. The choices of pro-inflammatory foods were initially based on studies showing that certain foods like trans-fatty acids (unsaturated fats) caused a spike in serum inflammatory markers in people.
– Autoimmune Protocol Diet
The Autoimmune Protocol (AIP) is a diet that aims to reduce inflammation, pain, and other symptoms caused by autoimmune diseases, such as lupus, inflammatory bowel disease (IBD), celiac disease, and rheumatoid arthritis (pubmed).

Many people who have followed the AIP diet report improvements in the way they feel, as well as reductions in common symptoms of autoimmune disorders, such as fatigue and gut or joint pain. Yet, while research on this diet is promising, it’s also limited.

The AIP diet is an elimination diet designed to help reduce inflammation or other symptoms caused by autoimmune disorders.

It’s comprised of two phases designed to help you identify and ultimately avoid the foods that may trigger inflammation and disease-specific symptoms. Research on its efficacy is limited but appears promising.

Due to its limited downsides, people with autoimmune disorders generally have little to lose by giving it a try. However, it’s likely best to seek guidance from a qualified health professional to ensure you continue to meet your nutrient needs throughout all phases of this diet.
– Choose My Plate
The Food Pyramid many of us grew up with has been replaced with a colorful plate that emphasizes proper proportions. One important message: Fill half your plate with vegetables. Learn more at
– Exercise
– Manage stress.
Chronic stress contributes to inflammation. Meditation, yoga, or guided imagery may help manage stress throughout the day.
Yes, antioxidants can reduce inflammation. They protect the tissues from damage by oxidation and free radicals which may have caused inflammation.
Vitamin C could be the best antioxidant for inflammation. This powerful antioxidant reduces inflammation by neutralizing the free radicals that damage your cells.

Best Natural Antioxidant Supplements for Inflammation

1. Eva Naturals Skin Clearing Serum Vitamin C+, 30ml



– 2% Retinol, 3.5% Niacinamide, 5% Hyaluronic Acid, 2% Salicylic Acid, 10% MSM, 20% Vitamin C 
– Skin Clearing, Anti-Aging Skin Repair, Face Serum
Best Anti Aging Serum 
Loaded with antioxidants, helps protect against UV rays while repairing sun-damaged skin. For an anti-aging boost, Hyaluronic Acid provides incredible hydration by holding up to 1000 times its weight in water!
Glowing Complexion 
Acne and other skin conditions leave your complexion looking red and uneven. The Niacinamide found in our formula supports healthy skin by naturally reducing inflammation and soothing troubled skin for an overall more even skin tone! This is also an effective dark spot corrector and hyperpigmentation treatment.
Best Acne Treatment 
When dirt and oil clogged pores,  they become larger and more visible. Retinol works to cleanse the pores, thereby making them appear smaller. Add to that the exfoliating effects of Salicylic Acid, and our serum is ready to fight blemishes and improve acne prone skin. A powerful alternative for products like Retin A, aha serums, hydroquinone and other retinoid products on the market.
Natural Skincare 
Packed with vitamins, essential oils, and organic ingredients like Aloe, our organic vitamin c serum is an adult acne treatment and dry skin facial treatment all in one! We focus on natural ingredients to keep our formula safe and effective for all skin types.
4.3 out of 5 – 40,485 global ratings
This stuff is so amazing, after just a couple of weeks of use I saw such a difference (and I’m 60 years old!)…honestly, I keep touching my’s so smooth and soft and moisturized!

2. Spirulina - KOS Organic Spirulina Powder



Spirulina organic powder is a nutritious blue green algae packed with organic protein, amino acids, and vitamins & minerals such as calcium, vitamin B, iron, potassium, magnesium & niacin. It gives a boost to blood iron levels, which promotes oxygen circulation within the body. Spirulina contains all essential amino acids & is a complete protein source, helping to revitalize muscles.
more about this product:
– Rich in Protein, Vitamins, Antioxidants, Fiber 
– Rich in chlorophyll. It may also help strengthen gut flora & promote digestion like a fiber supplement.
– Potent anti-inflammatory properties from phycocyanin & beta carotene, powerful antioxidants that fight free radicals and reduce oxidative stress. 
– It may also provide immune system support.
– Processed in a GMP & NSF certified facility. 
– Verified Third Party tested to ensure purity, potency and quality.
If you’re on this page, you already have a good idea of the potential health benefits. Gram for gram, spirulina may be the single most nutritious food on the planet – it is a true superfood. I have chronic anemia, so this is one of the many reasons I wanted to add this to my regimen. I put one very small scoop (recommended serving) into my morning smoothie – no taste, but it has a beautiful dark green color. I’ve been using this for a few weeks and feel great. Highly Recommend!
4.5 out of 5 – 1,459 global ratings

3. Green Tea - Zenwise Green Tea Extract



– Also used as a weight loss suppplement
– With EGCG & Vitamin C 
– Antioxidant & Immune Supplement 
– Vegan Skin & Heart Support + Brain Health & Memory Boost 
– Helps provide energy, and support for better mental focus and memory, heart health, and metabolism & weight management.
– Has 725mg of Green Tea Extract (Camellia sinensis) and 60mg of Vitamin C to provide additional antioxidant support.
– 120 Serving Supply. 1 capsule up to two times daily.
This supplement does really well with fat in the stomach area, and the sides where the “love handles” usually are. Now it is a supplement, so don’t expect to down a pill, not exercise and lose 10 pounds in a week, ain’t gonna happen. You have to practice good habits to see results. I eat clean and exercise 5-6 days out of the week. I keep 1 or 2 “me” days to keep sane. We’re still gonna die no matter how slim and healthy we are. So enjoy some kind of indulgence during your journey, it won’t kill ya, haha. Seriously though, during my 6 month journey, only taking the pill on my exercise days. I’d take 1 in the am with a small breakfast, exercise for a good hour or so, and eat clean on my “exercise” days. I lost 70 pounds!!!(about 11lbs a month). Make sure you eat with the pill as I have experienced nausea when I didn’t eat enough with it. Use these to aid you!! Not to make a miracle!! Excellent results, no side effects….5 stars from me baby!!
4.3 out of 5 – 5,724 global ratings

4. Alpha-Lipoic Acid (ALA) - Nutricost Alpha Lipoic Acid



Alpha-lipoic acid (ALA) is an antioxidant also known as Acetate Replacing Factor, ALA, Biletan, Lipoicin, Thioctan, and many other names that is produced naturally in the body and is also found in various foods. Red meats are particularly good sources of ALA, but you can also find in plant sources such as broccoli, spinach, and tomatoes.
Alpha Lipoic Acid plays an active role in your body at a cellular level. Our body make Alpha Lipoic Acid naturally; however, if the body does not produce the necessary amount, it is not able to produce all the benefits one needs. 
more about the item:
– Gluten Free, Vegetarian Capsules, Soy Free & Non-GMO
– 600mg of Alpha Lipoic Acid (ALA) Per Serving (300mg in each capsule). 
– Consists of both S-Alpha Lipoic Acid (S-LA) and R-Alpha Lipoic Acid (R-LA). 
– 240 capsules (120 servings for a full 600mg strength serving). Take both capsules together or one capsule in the morning and one in the evening.
– No milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat and soybeans. 
4.6 out of 5 – 14,721 global ratings

5. Resveratrol - Toniiq Ultra High Purity Resveratrol Capsules



Resveratrol is another nutrient that has antioxidant and anti-inflammatory properties.

In a 2018 study, scientists gave 110 people with mild to moderate OA of the knee a 500-milligram dose of resveratrol or a placebo. They took this combination alongside a 15-gram dose of the NSAID meloxicam every day for 90 days.

People who took resveratrol found that their pain levels dropped significantly, compared with those who took the placebo. Still need more research to confirm that resveratrol can benefit people with OA.

However, if you’re already taking another NSAID and it doesn’t reduce your pain as much as you’d like, the research suggests Resveratrol may be a useful add-on.

more about this item:
– Toniiq Resveratrol capsules contain 600mg of resveratrol in each serving
– 98% standardized purity
– Produced in a GMP-certified and NSF-approved manufacturing facility in the USA.
– Tested for additives, contaminants, and impurities 
I like the standardisation to 98%, I take 3 capsules in the morning and 3 at night. I am taking it for kidney disease. All the studies that show protection for the kidneys is in the amount of 2000mg or more. I will have to buy this supplement 3 times a month, pretty expensive. Wish they sold larger amounts Or they made this in a stronger strength so I wasn’t spending $54. A month to get a therapeutic dose. However, my recent kidney blood tests showed my numbers are back to normal. I also take Coenzyme Q10 in the average dose. I highly recommend this brand.
4.6 out of 5 – 4,477 global ratings

6. Zinc - Nature's Bounty Immune 24 Hour +



– Best Zinc Supplement for Seniors
– Contains 1000mg of Ester-C, the only clinically studied Vitamin C with 24-hour immune support. 
– Provides Vitamin D, Vitamin A and Zinc for extra immune plus antioxidant support. Also contains Elderberry and Echinacea, plus 9 essential nutrients.
– Non-GMO and contains No artificial flavor or artificial sweeteners, no sugar, no starch, no milk, no lactose, no soy, no gluten, no wheat, no yeast, no fish, sodium free.
– Take 2 soft gels daily, preferably with a meal.
So I got diagnosed with COVID. Best two weeks of my life. Lost my taste of taste/smell, go to the doctor, boom COVID. Two week quarantine with my buddy at his place= two week paid vacation from work to drink beer and play video games. No other symptoms but the taste and smell thing. This isn’t about COVID though its about the product.
I took this coupled with a dosage of Vitamin-D3 and I felt healthy as an ox in no time, taste and smell came back after a few days too. I was able to enjoy my foods and beverages again.
Easy to swallow, No bad flavors, Good product.
Saved my life from COVID.
4.8 out of 5 – More than 30,000 customer reviews 

7. Molecular Hydrogen (H2)

Yes, we are referring to H2, the smallest molecule on planet Earth. A relatively new comer in the field of regenerative medicine, molecular hydrogen is gaining popularity.

The publication of a landmark study in 2007, reported in a reputable journal (Nature Medicine) by a team in Japan, discovered that inhaled hydrogen gas could act as an antioxidant and protect the brain from free radicals. This sparked the interest in its potential health benefits worldwide and led to many published and on-going clinical research.

Following the landmark publication in Nature Medicine in 2007, many other studies regarding the potential application of hydrogen therapy on various conditions were subsequently published.

Since the Japanese discovery, the effects of hydrogen have been researched in 63 diseases [Source]!

It’s less known that hydrogen was therapeutically used for the first time in humans in the early 90s. It was given to 3 divers to successfully help them overcome the effects of high pressure on the brain in deep-sea diving [SourceSource].

Hydrogen is the smallest existent gas molecule.
Because of this unique property, molecular hydrogen could penetrate into virtually every organ and cell in the body (including the brain) where it may have antioxidant, anti-inflammatory, weight-loss, and anti-allergy activity. Molecular hydrogen seems like the perfect therapeutic the world has been eagerly searching for – with very few known side effects and such wide-ranging action [Source, Source].

Hydrogen water is loaded with hydrogen molecules. It was formulated as the most practical and easy way to get hydrogen into the whole body. But it’s not the only way – hydrogen can also be inhaled, injected, or absorbed through a bath [Source].
The ability of molecular hydrogen (H2) to protect the DNA and the mitochondria from oxidative damage may have beneficial effects on chronic diseases and cancer. But perhaps it could help slow down or reverse the aging process itself. A couple of cellular studies give us some interesting clues [Ref, R].

It was already discovered that hydrogen can prolong the life of stem cells by reducing oxidative stress [Ref].

A hydrogen-rich environment reduced both oxidative stress and aging in cells. Some scientists think
that drinking hydrogen water could increase longevity in humans (Circ J. 2016).

Related: Hydrogen Water As An Antioxidant – A 2020 Research Update

Online Shopping Guide

Before adding a new supplement to your routine, discuss its use with your healthcare provider, especially if you have an underlying health condition or are taking medication.

While many of the anti-oxidant supplements may be available in your local stores, it may be more convenient or affordable to shop for them online on Amazon (US):



Skin health
Remembering that Vitamin C has an important role in collagen formation, Vitamin C may help to heal damaged skin, as well as keeping it nourished and healthy. Moreover Vitamin C is important for antioxidant protection which help to give skin protection against oxidative damage produced by free radicals, UV, and pollution.

Anti-inflammatory effect
In hypertensive and/or diabetic obese patients, vitamin C (500 mg twice daily) has the ability to reduce inflammatory status by lowering hs-CRP, IL-6, and FBG. [Trusted Source]

Boost Immunity
One of the main reasons people take vitamin C supplements is to boost their immunity, as vitamin C is involved in many parts of the immune system.
First, vitamin C helps encourage the production of white blood cells known as lymphocytes and phagocytes, which help protect the body against infection (PubMed).

Second, vitamin C helps these white blood cells function more effectively while protecting them from damage by potentially harmful molecules, such as free radicals.


Other benefits of Vitamin C
A review of 28 studies (Diabetes Care. 2021 Feb) in 1,574 people with type 2 diabetes mellitus, demonstrated that vitamin C supplementation may improve blood sugar control and blood pressure in people with type 2 diabetes.

People who have pneumonia tend to have lower vitamin C levels, and vitamin C supplements have been shown to shorten the recovery time (PubMedPubMed).


A large review of 29 studies in 11,306 people demonstrated that regularly supplementing with vitamin C at an average dose of 1–2 grams per day reduced the duration of colds by 8% in adults and 14% in children (PubMed).


Interestingly, the review also demonstrated that regularly taking vitamin C supplements reduced common cold occurrence in individuals under high physical stress, including marathon runners and soldiers, by up to 50% (PubMedPubMed).


Additionally, high dose intravenous vitamin C treatment has been shown to significantly improve symptoms in people with severe infections, including sepsis and acute respiratory distress syndrome (ARDS) resulting from viral infections (PubMedPubMed).

Zinc is vital for many aspects of health and has been associated with a variety of benefits.

  • May Improve Immune Function
  • May Promote Blood Sugar Control
  • Helps Fight Acne
  • May Improve Heart Health
  • Slows Macular Degeneration