Best Arthritis Cream for Knees in USA 2022

Arthritis is the swelling and tenderness of one or more joints. The main symptoms of arthritis are joint pain and stiffness, which can worsen with age. The most common types of arthritis are osteoarthritis and rheumatoid arthritis.


If you have mild or moderate arthritis joint pain, a topical pain reliever may be useful to help ease the symptoms. Topical painkillers are available as creams, gels, roll-on and patches. They work to reduce pain in several ways.

Arthritis symptoms

The symptoms you experience will vary depending on the type you have. Common symptoms of arthritis:

– Joint pain, tenderness and stiffness

– Swelling and around the joints

– Decreased range of motion.

– Warm red skin over the affected joint

– Weakness and muscle wasting

Do topical creams help arthritis?

Some studies suggest that many NSAID creams and gels work as well as their oral counterparts. Therefore, for those who can’t tolerate oral NSAIDs, topical NSAIDs might be used instead. However, they should not be used if you are also taking oral NSAIDS. In the United States, the Food and Drug Administration has approved several NSAIDs topical products (for instance Voltaren)


Arnica is also very popular for treating arthritis. Arnica is a sunflower family herb whose flowers are used medicinally to treat stiffness and pain. Moreover, arnica also has anti-inflammatory properties.


In addition to arnica, you might also heard menthol, methyl salicylate (evergreen oil), and camphor in topical cream’s ingredients. They are known as counterirritants because it can produce a burning or cooling sensation over the painful joint or muscle, which may help soothe painful arthritis joints.


However, if you prefer strong or intense sensation, best to choose cream with capsaicin as their active ingredients. Capsaicin is the active element in hot chili peppers, is also one of the most efficient ingredients for can treating joint pain due to arthritis and other painful musculoskeletal conditions.

Best Arthritis Cream for Knees in USA

1. Penetrex Joint and Muscle Therapy Cream - Best Muscle and Joint Relief Cream

– Penetrex Pain Relief Cream
– Intensive Concentrate for Relief & Recovery 

– Whole-Body Formula with Arnica, Vitamin B6 & MSM (DMSO2) 

– Penetrex is recommended for use on its own & is safe to use in conjunction with complementary therapies such as Heating Pads, Ice Packs, Back Massagers, Knee Braces and Supplements.
– Relief & Recovery for Joints & Muscles on your Back, Neck, Knee, Hand, Foot, and more. 
– Contains unique ingredients including Arnica, Glucosamine, MSM (DMSO2), Choline, Boswellia Serrata (Frankincense) & Vitamin B6 deep into the tissue to soothe affected areas.

– Vanishing scent / non-greasy / non-sticky / non-staining / paraben-free 

– Vegan and Cruelty-free (never tested on animals).

4.3 out of 5 – more than 70,450 global ratings

Penetrex Pain Relief Cream Reviews
I was skeptical going in to an all natural pain relief cream for joints. I’ve had knee problems since I got out of the Army, and have broken a kneecap as well. Running makes my arthritis act up, and between this cream and a knee compression sleeve, after 3 days I had no more pain while running. I’m honestly amazed.

2. Topricin Pain Relief Therapy Cream

Topricin Pain Relief Cream

Topricin is moisturizing, non-irritating, odorless and non-staining. It supports the body’s natural processes that work to Heal the Cells Causing the Pain.

Topricin contains 11-natural biomedicines delivering reliable pain relief, improving quality-of-life, and providing a strong adjunct to professional care with no side effects and won’t interfere with other medications

The safest alternative for people who cannot tolerate prescription and non-prescription OTC oral pain medication. It stimulates and supports your body’s desire to “”Heal the Cells that are Causing the Pain””. Topricin is safe effective and ideal treatment for the entire family and for all skin types.


4.4 out of 5 – more than 4,800 global ratings

Topricin Pain Relief Therapy Reviews
I have very bad arthritis in my knees, hips and elbows, not to mention the muscle pain that comes with all of that. THIS STUFF WORKS!!!! I have used a lot of products, even one specialty prescription ointment that cost me over sixty-five bucks a month and Topricin Cream works better than anything I’ve used, It takes a few minutes to massage it into the skin and by the time i’s absorbed the pain is going going gone. Seriously, within ten minutes of rubbing it in my joints are feeling relief. Try it I think you’ll like it.

3. Bengay Ultra Strength Topical Pain Relief Cream

4-ounce tube of non-greasy Bengay Ultra Strength Topical Pain Relief Cream to ease backaches, minor arthritis, muscle, and joint pain. Topical analgesic contains three pain-relieving ingredients—camphor, menthol, and methyl salicylate, for ultra-strong relief in a non-greasy cream. Bengay is a physician-recommended OTC topical analgesic. Contains more pain-relieving ingredients than any other Bengay product.


– Non Greasy

– Relieves the minor aches and pains of muscles and joints

4.5 out of 5 – more than 8,900 global ratings
Bengay Ultra Strength Pain Relief Cream Reviews

4. Aspercreme Maximum Strength Pain Relief Cream with Aloe

Maximum strength Aspercreme is a topical pain relief cream. Trolamine salicylate 10% is the active ingredient, a topical analgesic. Trolamine is applied to where you need it, providing targeted therapy. Rub directly onto the affected area, such as your back or knee.

Aspercreme does not include aspirin. Aspirin is a salicylate, closely related to trolamine salicylate, the active ingredient in Aspercreme. If you are allergic to aspirin, consult your doctor before using Aspercreme.

– Best pain relief cream for tendonitis

4.5 out of 5 – more than 4,900 global ratings
Aspercreme Max Strength Pain Relief Reviews

5. NOW Solutions, Joint & Muscle Cream with Capsaicin and Boswellia

Formulated for use on the skin surrounding active joints and muscles. This product contains glucosamine, a compound normally found in the articular cartilage of joints, as well as boswellia, capsacin, and methyl salicylate.

– Paraben Free

– Cruelty Free

– GMP Quality Assured

4.3 out of 5 – more than 100 global ratings
NOW Solution Capsaicin  and Boswellia Cream Reviews:
You have to be careful using this, but it really works better than anything I have ever tried. Put it on my knees at night for a good night of rest. When I shower in the morning, I can still feel the heat.

6. Kneipp Arnica Joint & Muscle Intensive Cream

Kneipp Arnica Joint & Muscle Cream

Kneipp arnica cream contains arnica tincture for a powerful dose of botanical soothing benefits released by nature. Overworked, exhausted muscles and pangs don’t stand a chance against this intensive solution. It is easy to apply and fast acting so you can get back to your schedule.
– Vegan and contain no harmful preservatives, parabens or mineral oils.
– Soothe and comfort joints and muscles
– Best pain relief cream for joint pain

Benefits of Arnica Extract
– Help reduce pain related to sore muscles and joints
– Help heal bruises faster
– Aid in reducing swelling and inflammation
– Help speed recovery
– Help ease joint stiffness and aches
– Help reduce swelling from insect bites


4.5 out of 5 – more than 400 global ratings

Kneipp Arnica Muscle Pain Relief Cream Reviews
Relieves night time leg cramps in seconds . Also works wonders on my arthritic knee pain.

7. DULÀC Arnica Gel Cream Maximum Strength

The very high concentration of Arnica montana extracts (35%) makes our Arnica gel cream ideal for massages dedicated to bruise, swelling and discomfort in muscles and joints. Enriched with essential oils of mint and eucalyptus, which refresh the area for a long time giving topical relief. atural formula, suitable even for the most sensitive skin of babies. Salve without parabens, without mineral oils, without silicones

– Made in Italy. 

– Dermatologically tested and have a natural formulation

– Muscle and Joint relief

– Perfect for insect bites | Goodbye itching!

4.7 out of 5 – more than 800 global ratings
Dulac Arnica Gel Cream Reviews
I’ve been using this product for over 6 months and I am ao very grateful I found it. It is my go-to remedy for my my bruises, knee, joint and hip pain.


– Stay at a healthy weight. Extra pounds put pressure on weight-bearing joints like hips and knees. Each pound you gain adds nearly four pounds of stress on your knees and puts six times the pressure on your hips.
– Control your blood sugar. High blood sugar can stiffen the tissue that supports your joints and make them more sensitive to stress.
– Exercise. Just 30 minutes of exercise five times a week helps joints stay limber and strengthens the muscles that support your knees and hips. Focus on low-impact exercises like walking, cycling or swimming.
– Stretch. Gentle stretching can improve your range of motion and keep your joints limber. Try to work in simple stretches into every day.
– Avoid injury. An injured joint is more likely to develop arthritis than one that was never injured. Wear protective gear when playing sports and always lift with your knees and hips, not your back. 
– Quit smoking. Smoking puts stress on tissues that protect your joints and can lead to arthritis pain. Learn how Blue Cross can help you quit.
– Eat fish twice a week. Eat fish high in Omega-3s, like salmon, trout and mackerel. Omega-3s have many health benefits and may reduce inflammation.
– Get routine preventive care. Your doctor may be able to suggest lifestyle changes that can help reduce your risk or slow the progress of arthritis.
– Anti-Inflammatory Diet

Researchers have identified certain foods that can help control inflammation. Many of them are found in the so-called Mediterranean diet, which emphasizes fish, vegetables and olive oil, among other staples.
There’s a standardized research tool that’s updated regularly that allows anybody to see if they’re eating foods we know cause chronic inflammation. This is called the The Dietary Inflammatory Index or DII. The choices of pro-inflammatory foods were initially based on studies showing that certain foods like trans-fatty acids (unsaturated fats) caused a spike in serum inflammatory markers in people.
– Autoimmune Protocol Diet

The Autoimmune Protocol (AIP) is a diet that aims to reduce inflammation, pain, and other symptoms caused by autoimmune diseases, such as lupus, inflammatory bowel disease (IBD), celiac disease, and rheumatoid arthritis (pubmed).

Many people who have followed the AIP diet report improvements in the way they feel, as well as reductions in common symptoms of autoimmune disorders, such as fatigue and gut or joint pain. Yet, while research on this diet is promising, it’s also limited.

The AIP diet is an elimination diet designed to help reduce inflammation or other symptoms caused by autoimmune disorders.

It’s comprised of two phases designed to help you identify and ultimately avoid the foods that may trigger inflammation and disease-specific symptoms. Research on its efficacy is limited but appears promising.

Due to its limited downsides, people with autoimmune disorders generally have little to lose by giving it a try. However, it’s likely best to seek guidance from a qualified health professional to ensure you continue to meet your nutrient needs throughout all phases of this diet.